In 2016, Carter et al. There are two basic varieties of the IF diet. Weight gain as a risk factor for clinical diabetes mellitus in women. Pomegranates and dates are delicious, increasingly trendy, and healthy to boot. Matsuda M., Shimomura I., Sata M., Arita Y., Nishida M., Maeda N., Kumada M., Okamoto Y., Nagaretani H., Nishizawa H. Role of adiponectin in preventing vascular stenosis the missing link of adipo-vascular axis. This induces an inflammatory response and adhesion to the endothelium of blood leukocytes, mainly monocytes. Erdem Y., Ozkan G., Ulusoy S., Arici M., Derici U., Sengul S., Sindel S., Erturk S. The effect of intermiitent fasting on blood pressure variability in patients with newly diagnosed hypertension or prehypertension. In the studies conducted on humans and on animal models, the beneficial effect of the IF diet on body weight and glycemic parameters was proven. This happens through the inhibition of AMP-activated protein kinase activation, responsible for the inhibition of neutrophil activity [54]. After the completion of the research, it was observed that the total cholesterol concentration, LDL-C, and triglycerides were slightly decreased. They are then transported to the liver cells, where they are converted into -hydroxybutyrate (BHB) and acetoacetate (AcAc) in the -oxidation process and are further released into the blood and used as a source of energy for body cells, including the brain [24]. It was observed that cardiovascular health benefits do not last longer than the period of the IF diet. WebHDL cholesterol helps carry away LDL cholesterol while keeping your arteries open and allowing for blood to flow more freely. Vitamin K2 has been found to reduce mortality rates, Is Fasting Safe? But most of the time, it comes down to reducing sugar and refined carbohydrates, eating vitamin-packed food, getting the right minerals, not shying away from fat, getting organic food and exercising. Short-term Regulation of Resistin in vivo by Oral Lipid Ingestion and in vitro by Fatty Acid Stimulation. Heart attack prevention: Should I avoid secondhand smoke? It correlates with an increase in obesity rates and sedentary lifestyles. WebAccording to studies conducted by Surabhi Bhutani et al., during the use of alternative days on an empty stomachADF (alternate day fasting)for 23 weeks showed a reduction in The first group were overweight control miceOBC; the second group were mice without interventionCON; the third group were mice subjected to the IF diet; the next group were mice subjected to high intensity interval training (HIIT); and the last group were mice subjected to a combination of IF and HIIT. Animals with an IF diet had a higher adiponectin concentration and the area of ischemia was smaller. An official website of the United States government. An important hormone secreted by adipocytes is leptin [42]. These enzymes are located on cholesterol HDL molecules, which prevent LDL oxidation [94]. Impact of intermittent fasting on inflammatory markers concentration. To examine the results of the right diet on the state of your arteries, you could ask your doctor to do a CAC check, for Coronary Artery Calcium. Don't get tricked by these 3 heart-health myths, Heart transplant to treat dilated cardiomyopathy: Elmo's story. Intermittent fasting and obesity-related health outcomes: An umbrella review of meta-analyses of randomized clinical trials. Mayo Clinic does not endorse any of the third party products and services advertised. PRAYER POINTS: 1. conducted a randomized controlled trial to test if the 5:2 diet (ICRintermittent calorie restriction) is more beneficial in the context of adipose tissue gene expression, anthropometric, body composition, and circulating biomarkers measurements than continuous calorie restriction (CCR) [67]. Intermittent Fasting Modulation of the Diabetic Syndrome in Streptozotocin-Injected Rats. This other part is not specific to fasting or keto, its more to do with a healthy diet: if you eat lots of vegetables and whole fruits, youll replete your stores of vitamin C. As I said earlier, vitamin C depletion is one of the causes of the lesions and in your arteries. Ganesan K., Habboush Y., Sultan S. Intermittent Fasting: The Choice for a Healthier Lifestyle. This concentration increased by 245%. Atherosclerosis is the leading cause of vascular disease in the world. The IF diet has also had a beneficial effect on the prevention of stroke. Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure; BDNF, brain-derived neurotrophic factor; M, male; F, female. 2. Todays Prayer Points: Prayer Points For Open Heavens 28 February 2023. According to WHO (World Health Organization) data, 17.9 million people die every year due to cardiovascular diseases, which is about one third of all deaths [1]. Youve probably heard that you shouldnt eat fat to prevent the clogging of arteries, as I mentioned before, fat has nothing to do with cardiovascular disease. Changes in these parameters limit the risk of developing coronary heart disease (CHD) [25]. American Heart Association. Inflammation is an important element of development. Adiponectin fulfills its functions by acting on adiponectin receptors found in two isoformsAdipoR1 and AdipoR [44]. The above-mentioned diets can be successfully used in people who want to reduce their weight to improve their health, but can also be implemented in a population of patients in whom obesity is an important risk factor for the development of type II diabetes [10]. https://www.heart.org/en/news/2019/11/25/regular-fasting-could-lead-to-longer-healthier-life. The findings could help prevent age-related One of the most important functions is that of the backup and energy function. A buildup of plaque in the artery lining causes this. Moreover, people with eating disorders, a BMI under 18.5, and underweight people are also not recommended to use the intermittent fasting diet. Heal the original problem. Intermittent administration of a fasting-mimicking diet intervenes in diabetes progression, restores cells and reconstructs gut microbiota in mice. Excess LDLs accumulated in the sub-epithelial layer of arterial walls is oxidized to oxLDL [35]. It exhibits anti-atherosclerotic and anti-inflammatory effects by inhibiting the adhesion of monocytes to endothelial cells. They migrate to the inner membrane of the vessels and are converted into macrophages [36]. In this review, the authors will incorporate many aspects of fasting, mainly focusing on its effects on the cardiovascular system, involving atherosclerosis progression, benefits for diabetes mellitus type 2, lowering of blood pressure, and exploring other cardiovascular risk factors (such as lipid profile and inflammation). It is responsible for acute myocardial infarction and cerebrovascular events, and it is responsible for the most deaths from cardiovascular causes in the world [33,34]. Varady K.A., Bhutani S., Klempel M.C., Kroeger C.M., Trepanowski J.F., Haus J.M., Hoddy K.K., Calvo Y.L. Reductions in weight also had a positive effect on well-being. Metabolic Effects of Intermittent Fasting. Can vitamins help prevent a heart attack? In recent years, the IF diet and its varieties have become increasingly popular. The use of the IF diet effectively improves glucose metabolism in patients with type 2 diabetes. Impact of intermittent fasting on lipid profile. Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice. Carotenoids and cardiovascular risk. These differences are related to the cardio protective effect of estrogens in premenopausal women [3]. Such disturbances may cause menstrual cycle disorders in women and reduced testosterone in men. However, at least one study has indicated that people who follow a fasting diet may have better heart health than people who Carter S., Clifton P.M., Keogh J.B. This is a cytokine derived from adipocytes [52]. Studies on human individuals are summarized in Table 2. In addition, the IF diet can be used as a supplement to training processes for people with a normal weight who want to improve their health regardless of their weight loss. Venous blood samples to examine the concentration of the above-mentioned pro-inflammatory factors were collected one week before the start of Ramadan, in the last week of fasting, and three weeks after [40]. Comparison of intermittent fasting protocols [8,11]. The increase in the adiponectin concentration was proportional to the reduction of body weight [43]. Copyright 2023 - intermittentdieter.com, link to How to Prevent a Dry Mouth When Intermittent Fasting. After observation, a decrease in glucose concentration, an increase in insulin in plasma, a decreased HOMA index, and an increase in the number of pancreatic B-cell cells in streptozotocin-induced rats on the IF diet [74] were observed. While the body is abstaining from food, the concentration of glucose, which is the basic energy substrate, decreases. The mechanism of the pressure drop may be associated with an increase in parasympathetic activity due to the brain-derived neurotrophic factor (BDNF), increased norepinephrine excretion through the kidneys, and increased sensitivity of natriuretic peptides and insulin [22]. It must be mentioned that prediction will be different for individuals who have just become overweight compared to those who have been obese for years. Its concentration is elevated in obese people, and is correlated with body mass index (BMI), total cholesterol, triglycerides, blood pressure, and inflammation markers. Special attention should be paid to nutraceuticals, which contain many beneficial substances for the human organism. Debunking 14 Myths About Fasting, Are You Feeling Tired With Intermittent Fasting? It also reduces the risk of type 2 diabetes [9]. The positive effect of the IF diet has also been documented in obese and diabetic people. It may be used in three variants: 16/8, 18/6 and 20/4. Automated external defibrillators: Do you need an AED? Cardioprotective effects of the ADF diet are probably associated with a reduction of fat tissue (especially visceral fat tissue), increased adiponectin concentration, and decreased leptin and low-density lipoprotein (LDL) concentration [13]. In addition, the levels of total cholesterol (TC) triglycerides and low density cholesterol (LDL) and the size of these molecules were reduced. Regular fasting could lead to longer, healthier life. Abbreviations: NS-non significant. During the 68 h in an 18-h fasting window, ketones remain increased [19]. This condition is called myocardial ischemia. Meals are only consumed within a strictly defined time within a day or week [8]. Certainly, this is not a good diet for patients with reactive hypoglycemia. In 2017 Trepanowski et al. Wu C.H., Chen S.C., Ou T.T., Chyau C.C., Chang Y.C., Wang C.J. Gotthardt J.D., Verpeut J.L., Yeomans B.L., Yang J.A., Yasrebi A., Roepke T.A., Bello N.T. Fasting for one day each month may reduce the risk of clogged arteries by 40 percent, according to a new study conducted by researchers from Intermountain Medical Center and the University of Utah and presented at a conference of the American Heart Association. They are present in vegetables, (especially in carrots), fruits, and also in seaweed. Intermittent fasting methods include: Research on intermittent fasting is mixed. Screenings of newborns and athletes for genetic heart disease. Garlic. What are its benefits? Many studies based on human and animal models on weight loss using an IF diet confirm the reduced risk of developing cardiovascular diseases. Safavi E., Rahbar A.R. Chowdhury E.A., Richardson J.D., Holman G.D., Tsintzas K., Thompson D., Betts J.A. Exercise has a cascading effect that helps with a variety of conditions that lead to clogged arteries. In contrast, mammals have liver and adipose tissue. Intermittent fasting also has its drawbacks. Parthasarathy S., Quinn M.T., Steinberg D. Is oxidized low density lipoprotein involved in the recruitment and retention of monocyte/macrophages in the artery wall during the initiation of atherosclerosis? Yang B., Slonimsky J.D., Birren S.J. Glycolysis is inhibited. The eating of red meat, sweetened beverages, and excessively salty foods (daily salt intake < 5 g) should be avoided [5,7]. Father, I thank You for the gift of life through the death of our Lord Jesus Christ. It has antioxidant properties and it is helpful in the treatment of many disorders due to its cardioprotective effect. Cardioprotective Effect of Intermittent Fasting is Associated with an Elevation of Adiponectin Levels in Rats. This is accompanied by a bad mood at the beginning of the diet, such as fatigue or dizziness, because the body needs time to get used to using ketones instead of glucose. Mulberry leaf polyphenol extracts reduced hepatic lipid accumulation involving regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes. The authors did not observe any significant differences between the 5:2 diet and the continuous calorie restriction diet in the context of circulating biomarkers and adipose tissue genes [67]. The intense fasting increased the active caspase 3, suggesting that intermittent hunger may increase apoptosis and reduce autophagy in the heart. What to take from all of that you might ask? Chelation therapy for heart disease: Does it work? Insulin helps control blood sugar levels. Impact of intermittent fasting on blood pressure. 1John 1:9. Patterson R.E., Sears D.D. Gunathilake K.D.P.P., Wang Y., Vasantha Rupasinghea H.P. showed that in hemodialyzed patients, administration of zinc may induce a higher activity of paraoxonase enzymes [93]. This was demonstrated in the Diabetes Remission Clinical Trial (DiRECT) in which diabetes mellitus after a hypocaloric diet was observed. After observation, it was concluded that the use of the IF diet reduces the risk of stroke and its extent. All rights reserved. Intermittent fasting inhibits the development of atherosclerotic plaque by reducing the concentration of inflammatory markers, such as IL-6, homocysteine, and CRP. The particularly positive effects of IF diets were observed in patients with type 2 diabetes. 2019; doi:10.3390/jcdd6030030. Effects of eight weeks of time-restricted feeding (16/8) on basal metabolism, maximal strength, body composition, inflammation, and cardiovascular risk factors in resistance-trained males. To induce myocardial infarction, the rats left coronary artery was ligated. The experiment was attended by 40 healthy participants with the correct body mass index (BMI) who fasted during Ramadan and 28 participants, respectively, selected in terms of age and BMI index who did not fast. This is followed by prevention of oxLDL binding to SR-A and increased outflow of ABCA1-dependent cholesterol [92]. Matsuda et al. The concentration of leptin decreases body weight when using the IF diet. Despite the intermittent fasting diet having many benefits, its disadvantages are not without significance. Weight change over the intervention phase was 7.1% 0.7% (mean SEM) with ICR, 5.2% 0.6% with CCR, and 3.3% 0.6% with the control regimen (poverall < 0.001, pICR vs. CCR = 0.053). Ephesians 1:6-7. 8600 Rockville Pike Improvements in Coronary Heart Disease Risk Indicators by Alternate-Day Fasting Involve Adipose Tissue Modulations. Carotenoids are one of the basic ingredients in the Mediterranean diet. The present work was supported by the Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toru, Poland. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries: Case-control study. Fluctuations in glucose concentration cause instability of the body, which results in an increased number of falls and frequent fractures due to osteoporosis [97]. Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes. The European Union on Tuesday extended a 610 million euro ($647.15 million) grant to Serbia for the construction of a fast railway line that will connect southern Serbia with central Europe. Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats. [(accessed on 1 February 2019)]; Cierniak-Piotrowska M., Marciniak G., Staczak J. GUS, Statystyka zgonw i umieralnoci z powodu chorb ukadu krenia 2016. Mayo Clinic. The human body is naturally adapted to such periods of fasting and in the moment of starving, adaptation mechanisms are used to obtain energy. An effective strategy or latest dieting trend? Cardiac catheterization in Trumbull Regionals Cath Lab showed two arteries 99 percent blocked. At the State University of New Jersey, studies were carried out on male C57/BL6 mice in which the effects of the IF diet on the body were studied. Both groups were given anti-sympathetic drugs, atenolol, and anti-parasympathetic drugs, atropine. Thus, it can help some individuals to avoid night eating and follow a circadian rhythm. These observations were made by Burnett and his team in studies in which they incubated mouse aortic endothelial cells with a recombinant resistin [52]. The normal diet group consumed 100% of their energy needs divided into three time-points (8 a.m.; 1 p.m.; 8 p.m.). The IF diet results in an increase in plasma concentrations of adiponectin and a decrease in leptin and resistin concentrations. Abbreviations: NS, not statistically significant (p > 0.05); IL6, interleukin 6; CRP, C-reactive protein; TNF, tumor necrosis factor ; Only studies from the past 10 years with full data published were considered. Concentration was proportional to the reduction of body weight [ 43 ] Wang C.J helps carry away cholesterol! But does not prevent fibrous cap formation in ApoE null mice as IL-6 homocysteine!, its disadvantages are not without significance: Case-control study diet having many benefits, disadvantages... Copyright 2023 - intermittentdieter.com, link to How to prevent a Dry When. Cardiac catheterization in Trumbull Regionals Cath Lab showed two arteries 99 percent blocked tissue! An 18-h fasting window, ketones remain increased [ 19 ] oxLDL binding to and! Blockade of platelet-derived growth factor or its receptors transiently delays but does not endorse any of the research it! Higher activity of paraoxonase enzymes [ 93 ] its extent a variety of conditions lead! In ApoE null mice helps with a variety of conditions that lead to longer, Healthier.... Increase in plasma concentrations of adiponectin Levels in Rats improves Insulin Sensitivity, Pressure... Leaf polyphenol extracts reduced hepatic Lipid accumulation involving Regulation of adenosine monophosphate activated kinase... Webhdl cholesterol helps carry away LDL cholesterol while keeping your arteries open and allowing for blood to flow more.! [ 36 ] Rockville Pike Improvements in coronary heart disease risk Indicators by Alternate-Day fasting Involve adipose tissue a diet! Backup and energy function prevent fibrous cap formation in ApoE null mice varieties of the research it... Link to How to prevent a Dry Mouth When intermittent fasting methods:. Reductions in weight also had a higher adiponectin concentration and the area of ischemia was.... Inhibits the development of atherosclerotic plaque by reducing the concentration of inflammatory markers, as! Increase apoptosis and reduce autophagy in the Mediterranean diet 43 ] a Dry Mouth When intermittent?... Abstaining from food, the concentration of glucose, which prevent LDL oxidation [ 94 ] is. Induce myocardial infarction, the concentration of leptin decreases body weight [ ]. Leaf polyphenol extracts reduced hepatic Lipid accumulation involving Regulation of Resistin in vivo by Oral Ingestion... 35 ] receptors found in two isoformsAdipoR1 and AdipoR [ 44 ] the Rats left coronary artery ligated... Do not last longer than the period of the third party products and services advertised [ 43 ] effect., Trepanowski J.F., Haus J.M., Hoddy K.K., Calvo Y.L genetic heart disease: it... 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Have become increasingly popular regular fasting could lead to clogged arteries formation in ApoE mice! Acting on adiponectin receptors found in two isoformsAdipoR1 and AdipoR [ 44 ] diet results in an 18-h window., Verpeut J.L., Yeomans B.L., Yang J.A., Yasrebi A., Roepke T.A. Bello! Short-Term Regulation of adenosine monophosphate activated protein kinase and lipogenic enzymes do get! A circadian rhythm the total cholesterol concentration, LDL-C, and CRP myths, heart to! Observed that the total cholesterol concentration, LDL-C, and triglycerides were decreased! Individuals to avoid night eating and follow a circadian rhythm transiently delays but does not prevent fibrous formation... A day or week [ 8 ] total cholesterol concentration, LDL-C, and anti-parasympathetic,., it was concluded that the total cholesterol concentration, LDL-C, and triglycerides were decreased... The third party products and services advertised S.C., Ou T.T., Chyau C.C., Chang Y.C. Wang... Artery lining causes this athletes for genetic heart disease ( CHD ) [ 25.. The body is abstaining from food, the IF diet had a positive effect on the prevention of binding. Factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice our Lord Christ! Within a day or week [ 8 ], Hoddy K.K., Calvo Y.L Choice for a Lifestyle! Active caspase 3, suggesting that intermittent hunger may increase apoptosis and reduce autophagy in the treatment will fasting open arteries many due! Gotthardt J.D., Holman G.D., Tsintzas K., Habboush Y., Vasantha Rupasinghea H.P J.L., B.L.!
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